National Academy of Clinical Biochemistry
Maternal-Fetal Risk Assessment and Reference Values in Pregnancy John E. Sherwin, Gillian Lockitch, Philip Rosenthal, Stephanie Rhone, Laura Magee, Edward R. Ashwood, Barbara M. Goldsmith, Carol R. Lee, Sharon Geaghan, Michael Bennett
This laboratory medicine
guideline was developed beginning with preconception issues and proceeding
through pregnancy identification, first and second trimester evaluation
of fetal health, to delivery and initial evaluation of the newborn. While
we have attempted to define the central laboratory medicine issues, this
is not a comprehensive listing of all possible events or the medical evaluation
that may be required. Our recommendations are based upon the consensus
of expert contributors and their experience in their field of expertise.
Some issues are not yet fully resolved, and may require us to revisit
this topic at some future date. The dietary addition of folic acid has
had a significant effect on the incidence of neural tube defects, and
we may see some continuation of this trend. The emerging role of first
trimester screening for fetal health will continue to develop, and there
is some suggestion that it may supplant at least a portion of second trimester
screening. The evaluation of the high risk infant at term continues to
increase in complexity as does the evaluation of the newborn infant.
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Copyright 2006 by the National Academy of Clinical Biochemistry